Antonio Banderas utilized his heart attack experience to inform his performance in Pedro Almodóvar's film, "Pain and Glory," for which he won the Best Actor trophy at the Cannes Film Festival. The actor revealed that the cardiac event, which occurred two and a half years prior to the film's production, profoundly altered his emotional landscape and perspective on life. Almodóvar recognized this change and encouraged Banderas to channel it directly into his portrayal of the character, a director suffering from physical and emotional pain.

Banderas described how the heart attack led to a shift in his emotional sensitivity. Previously considering himself a "tough guy" slow to cry, he found himself becoming more emotional, tearing up at movies and music. A nurse, while he was recovering, had told him that the heart stores feelings, and that he might experience sadness, which proved true. This heightened emotional state, coupled with Almodóvar's specific direction, allowed Banderas to deliver a performance that resonated deeply, earning him critical acclaim and his first Oscar nomination at 59 years old.

The heart attack also fundamentally changed Banderas's priorities. He stated that seeing death closely made him re-evaluate what truly mattered, shifting focus from career ambitions to his daughter, family, friends, and his vocation as an actor. He emphasized that artists create with their life experiences, good or bad, and that his personal brushes with mortality became tools for his acting, allowing for a more authentic and vulnerable portrayal in "Pain and Glory."

Almodóvar, known for his nuanced direction, specifically advised Banderas against exaggerated emotional displays, preferring actors to "hold back the tears" and be more economic with their emotions. Despite this, the director detected a new depth in Banderas post-heart attack and wanted him to embrace that raw vulnerability for the role, believing it would align closely with the film's themes of pain.