Lane Kiffin’s highly anticipated return to Oxford as the coach of LSU ended in a 32-24 upset loss to his former team, Ole Miss. The game, which marked Kiffin’s third at the helm of LSU, was dominated by Ole Miss quarterback Trinidad Chambliss, a player Kiffin had recruited from a Division II program to Ole Miss last year and unsuccessfully tried to lure to LSU. Chambliss delivered a stellar performance, passing for 363 yards and two touchdowns, and securing a tie-breaking 14-yard rushing touchdown in the fourth quarter.

LSU, despite a roster reportedly costing $50 million, displayed significant weaknesses. Their pass protection was shaky, and quarterback Sam Leavitt struggled with turnovers. The Tigers' secondary was consistently outmaneuvered, and their pass rush, which was previously a national leader in sacks, failed to effectively pressure Chambliss. Leavitt completed 16 of 27 passes for 158 yards with one touchdown and one interception, in addition to rushing for 63 yards and a score.

Ole Miss initially took a commanding 24-7 lead by halftime, with Chambliss throwing a 20-yard touchdown to Deuce Alexander. LSU managed to rally, tying the game at 24-24 in the fourth quarter after a 23-yard field goal. However, Chambliss responded with a 75-yard touchdown drive, culminating in his game-winning run and a subsequent two-point conversion that extended Ole Miss’s lead to 32-24. The Tigers had a final chance but Leavitt's fourth-down pass was intercepted in the end zone.

The game also highlighted the impact of Kiffin’s previous efforts, as he had played a role in securing Chambliss's eligibility for another year in college football. Kiffin expressed mixed emotions about his return to Ole Miss, acknowledging the deep feelings for the place where he had transformed the Rebels into an SEC powerhouse before his departure. The loss underscored the challenges facing LSU's new, expensive roster and the pivotal role Chambliss played for Ole Miss, especially after their top running back, Kewan Lacy, left the game with an injured left shoulder.