A 1720 painting, "Virgin of the Mountain of Potosí," housed in the Museo Nacional de Arte in La Paz, Bolivia, exemplifies the syncretic blend of Catholic and indigenous beliefs during the colonial period. This devotional image portrays the Virgin Mary merging with the Cerro Rico, the silver-rich mountain dominating Potosí. This visual combination, referred to by art historian Teresa Gisbert as syncretism, highlights how the Virgin's conical gown resembled sacred Andean mountains, thereby connecting her to Pachamama, the Andean divine feminine.

The painting's significance is understood in two main ways. For Spanish priests, this syncretism was a tool to facilitate the conversion of indigenous people to Catholicism. However, for colonized Andean artists, it served as an act of protest, a means to preserve and perpetuate their traditional beliefs and practices under the guise of Christian art. The Virgin Mary, specifically the Virgin of Copacabana, was also associated with the sacred mountain Llallagua, further solidifying this connection.

Historically, in 1582, the indigenous people of Copacabana, after experiencing crop failures and starvation, replaced their assigned patron Saint Ann with the Virgin Mary. This decision, viewed by the Spanish as seeking a better intercessor in a legalistic heavenly structure, was, from an Andean perspective, a re-establishment of a direct, familial relationship (ayni) with Pachamama, who they believed would reciprocate their offerings with rain and sustenance. This highlights the differing cultural interpretations of the divine and the purpose of religious figures. The painting, co-opting a familiar religious theme while infusing it with local meaning, serves as a powerful example of Andean religious expression during colonization.